д ϼ (STING) ̿ 鿪ġ

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д ϼ (STING) ̿ 鿪ġ
鿪 ׾ ʴ 鿪ġ Ըϰ ο ġ
๰, PD-1, ҿ ۽ ߺġ 40% ϼ ҽ
  • Է : 2021. 07.27(ȭ) 19:09
  • /簩
д ϼ
[/簩] ǰдб д ϼ ȫõ(系), (ܰ) ϼ Žϴ ϴ ܹ (STING, STimulator of INterferon Genes) ̿ 鿪 ׾ غϴ ġ ߴ. ̹ 鿪׾ġȸ(SITC) м 鿪ġ(Journal for ImmunoTherapy of Cancer, IF 13.751) ֽȣ ƴ.

츮󿡼 ° , κ ȯڴ 鿪 ׾ ġ . ̴ ų ȭϰ 鿪 ڽſ ǿϱ 鿪 ׾ ġῡ ʰ Ƴ .

̹ T(鿪) ݷ پ CD8 T ȭϰ, ϼ ϴ 鿪 η δٴ Ըߴ. CD8 T 鿪ܹ PD-1, LAG-3 ٹ Ǹ鼭 ϼ ϴ ȭ ƴ. 鿪 ϰ ϴ M2 ļ 8 ̻ Ȯεƴ.

鿪 ϴ ܹ ϼ Ž 鿪 ϵ غŰ Ѵ. ̵ 㿡 ๰ 41% ǰ, 56% ҵ Ȯߴ. Ư, 38% ٰ, ų CD8 T 2 , ׾ϱ Ⱓ 2 þ. ๰ ȿ ð Ÿ Ⱓ ƴ.

๰ ܵ ϸ پ 鿪 (PD-L1, COX2, IDO ) Ǵ ־ ȿ ϼ Ѵ. ش 10% ƿ Ұϴ.

̿ ϴ PD-1, COX2 鿪 ܹ ÿ ܵ ֵ PD-1 鿪 COX2 ϴ ҿ ۽(celecoxib) ϴ ߺġḦ ߴ. 40% ϼ , ߴ. Ư ü Ͽ ϴ 鿪޸𸮰 ϼ ٽ ص ϰ Ǵ Ȯεƴ.

å 系 츮󿡼 ſ 鿪׾ ִ 찡 3% Ұϸ, 97% ȯڿ 鿪׾ ġ ١ ׷ 鿪׾ġḦ ϰ ãƿ κ ȯڵ ۿ Ȳ̾. ̹ Ͽ 鿪׾ غ ִ ı ӻ ȴ١ Ǹ ߴ.

ܰ ߺ ӵ ϰ ִ  ȯڸ žళ߻ ƴ϶ ġᰡ Ұߴ ȯڵ鵵 ϴ ʰ ١ ̹ 鿪׾ ӻ ̾ ȯڵ鿡 ο DZ⸦ ٶ١ ߴ.

̹ бź ߰߿, óֱǷ⿬߻ , п(BRIC) ѱ (Ѻ) ƴ.
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