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ȭ BRCA̸ հ(HRD)缺 Ҿ ֿ ȯ ̽(Patient-derived tumor xenograft, PDTX)ϴ ̿ JPI-547 ü (In vivo) ȿ ߴ. ∙Ҿ öĸ(Olaparib), Żĸ(talazoparib) IC50(ϼ ų ִ ) ϼ ȿ Ȯ JPI-547 ȿ ߴ.
JPI-547 쿡 99% پ ȿ ̴ Ȯߴ. 1 öĸ(Olaparib) 58.2% ϶ĸ(Niraparib) 55.6% Żĸ(talazoparib) 66.2% ȿ Ϳ JPI-547 ϰ ȿ Ȯߴ.
7 ̻ öĸ ∙Ҿ JPI-547 (50mg/kg) 81.7% ȿ Ȯ ־.
д 系 ȭ ̹ JPI-547 غ ִ ο ġμ ɼ Ȯ ̾ ū ǰ ִ١ ȹ濡 ġ پ DNA ܹ RAD51 Ǵ Ŀ Ըߴ١ . ̾ غ ɼ Ȯ JPI-547 ̿Ŀ ɵ ְ ̶ ߴ.
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